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ENDOCRINE


ADRENAL

PromptADRENAL CRISIS
ResponseStem =Refractory shock unresponsive to fluid resuscitation
Adrenal crisis = Adisonian crisis = Cortisol insufficiency
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PromptADDISONIAN CRISIS
ResponseStem - shocked patient with long term steroid use
NAGMA, hypoglycaemia, hyponatraemia, refractory shock
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PromptGas findings in addisonian crisis
ResponseNAGMA
Hypoglycaemia
Hyponatraemia (+/- Hyperkalaemia) = Classic finding
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PromptManagement - Acute
ResponseCorrect hypoglycaemia - 50% 50mL
IV steroids (hydrocort 100 or dex 8mg IV)
Address hypotension
  • IV fluids up to 2L
  • Norad for map >65
Seek and treat cause - likely sepsis - Broad spectrum ABx (? Fluclox + Gent)
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PromptManagement - Chronic
ResponseEnsure patient has a β€œsick day plan” - typically doubling or tripling baseline steroid dosing
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PromptCARCINOID SYNDROME
Response
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PromptTumours commonly associated with Carcinoid syndrome
ResponseSmall bowel neuroendocrine tumours
Gastric/lung neuroendocrine tumours
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PromptMost important therapy to consider in carcinoid
ResponseOctreotide IV
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